宫颈癌的核心诱因是HPV（人乳头瘤病毒）感染，但从感染到最终确诊宫颈癌并非一蹴而就，而是需经历明确的渐进式病变过程：首先是宫颈低级别鳞状上皮内病变（LSIL，即CIN1），随后进展为宫颈高级别鳞状上皮内病变（HSIL，含中度CIN2与重度CIN3）。临床数据显示，从HPV感染发展为宫颈癌前病变通常需要5年左右；而从癌前病变进一步恶化为浸润癌，周期可长达10至20年。
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