为解决这一矛盾，研究团队从结肠癌肿瘤中分离出单个细胞，进行克隆并在体外培养。这些源自同一肿瘤的克隆细胞随后在体外系统和小鼠模型中接受评估，用以观察它们穿过生物学屏障并形成转移灶的能力。研究人员在大约30个来自两例原发结肠肿瘤的克隆细胞中，测量了数百个基因的活性水平，结果发现，不同细胞克隆之间存在清晰的基因表达梯度，这些梯度与细胞迁移能力的高低呈显著相关。
Let’s put this projection to real use. Here’s the video of a tesseract rotating in the XZ plane:
Explicitly multi-threaded tests are better but trickier because you have，更多细节参见safew
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Instead of perturbing each pixel in the input image at random, we can choose to dither by a predetermined amount depending on the pixel’s position in the image. This can be achieved using a threshold map; a small, fixed-size matrix where each entry tells us the amount by which to perturb the input value , producing the dithered value . This matrix is tiled across the input image and sampled for every pixel during the dithering process. The following describes a dithering function for a 4×4 matrix given the pixel raster coordinates :
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